The BEAUTIFUL study: randomized trial of ivabradine in patients with stable coronary artery disease and left ventricular systolic dysfunction – baseline. failure.9 A trial of ivabradine involving patients well as for the fidelity of this report to the trial tricular systolic dysfunction (BEAUTIFUL). The BEAUTIFUL Study: Effects of Ivabradine in Patients With Stable Coronary Artery Disease and Left Ventricular Systolic Dysfunction.

Author: Akinogore Tubei
Country: Serbia
Language: English (Spanish)
Genre: Business
Published (Last): 25 May 2018
Pages: 443
PDF File Size: 15.50 Mb
ePub File Size: 3.72 Mb
ISBN: 551-2-36881-272-1
Downloads: 94583
Price: Free* [*Free Regsitration Required]
Uploader: Voodoojind

You expect to receive, or in the past 4 years have received, shared grant support or other funding with any of the authors. F does not screen, edit, publish or review Material prior to its appearance on the website and is not responsible for it. Accordingly you may only post Material that you have the right to do so.

With the BEAUTIFUL Results, Procoralan* (ivabradine) is the First Antianginal Tr

You may not use the website for any unlawful purpose, including without limitation, to upload, post, download or otherwise use any Material that you do not have the copyright owners permission to so upload, post, download or otherwise use, or that would result in you being in breach of these terms and conditions.

No significant difference was seen with regards to the primary outcome. By posting or uploading Material you warrant and represent that: Digoxin may also be used in concomitant atrial fibrillation, whereas ivabradine cannot. By clicking “I accept the Terms and Conditions relating to Materials” before you submit your first Material as hereinafter defined you agree to be bound by these conditions every time you submit Material.

Sign in to My ESC. Reduction in heart rate with ivabradine does not improve cardiac outcomes in all patients with stable coronary artery disease and left-ventricular systolic dysfunction, but could be used to reduce the incidence of coronary artery disease outcomes in a subgroup of patients who have heart rates of 70 bpm or greater.


Examples of ‘Non-Financial Competing Interests’ Within the past 4 years, you have held joint grants, published or collaborated with any of the authors of the selected paper.

In the overall study population treatment with ivabradine did not result in a significant reduction of the primary composite end point Cardiovascular death, admission to hospital for acute MI and admission to hospital for heart failure.

Ivabradine is approved in Europe for the symptomatic treatment of chronic stable angina in coronary artery disease CAD patients who are in normal sinus rhythm and have a resting heart rate of 70 bpm or greater.

Hence the results of BEAUTIFUL constitute a step further in the management of these coronary patients with heart rate above 70 bpm because, for the first time it has been shown that pure heart rate reduction with ivabradine further reduces coronary events even in patients receiving the current optimal cardiovascular therapy.


Did you know that your browser is out of date? The primary endpoint was a composite of cardiovascular death, admission to hospital for acute myocardial infarction, and admission to hospital for ivabradihe onset or worsening heart failure.

The maximum recommended dose is 7. The primary outcome was time to first cardiovascular death, admission to the hospital for acute MI, and admission to the hospital for new onset or beauticul heart failure. Consider the following examples, but note that this is not an exhaustive list: Recommend to your librarian.



To date, there are no well-established, head-to-head studies comparing ivabradine with other rate-lowering medications used in heart failure, such as digoxin. We analysed patients by intention to treat.

No sponsor or advertiser has participated in, approved or paid for the content provided by Decision Support in Medicine LLC. Between December,and December,we screened 12 patients at centres in 33 countries. We aimed to test whether ebautiful the heart rate with ivabradine reduces cardiovascular death and morbidity in patients with coronary artery disease and left-ventricular systolic dysfunction.

To reduce the burden of cardiovascular disease.

In a prespecified subgroup of patients with heart rate of 70 bpm or greater, ivabradine treatment did not affect the primary composite outcome hazard ratio 0. These terms shall be governed by and construed in accordance with English Law. Powered By Decision Support in Medicine.

The study is registered with ClinicalTrials. In patients in normal sinus rhythm who cannot tolerate target doses of beta blockers or who experience high heart rates despite optimal beta blocker therapy, ivabradine may be a useful addition to standard heart failure therapy. The use of certain tools provided by this website is subject to additional Terms and Conditions.

There was a problem providing the content you requested

Administration The recommended starting dose of ivabradine is 5 mg by mouth twice daily with meals. However, it did reduce secondary endpoints: The primary composite endpoint was cardiovascular death or hospital admission for worsening heart failure. However, it did reduce secondary endpoints: